phenobarbital improves toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers may well increase the metabolism of ifosfamide to its Lively alkylating metabolites.Hypnotic doses of barbiturates never look to impair uterine activity appreciably for the duration of labor. Complete anesthet